The necessity of booster vaccination after neonatal hepatitis B vaccination
نویسنده
چکیده
Soon after introducing recombinant hepatitis B virus (HBV) vaccine, universal neonatal vaccination became the corner stone of the preventive measures for this potentially life threatening infection (1-3). By 2006 more than 177 out of 193 member states of world health organization (WHO) introduced HBV vaccination in their national infant immunization programs (1). Following a complete series of vaccination during neonatal period, protective antibody level raises in more than 95% of infant’s blood test up to 18 months after vaccination (3-5). The effectiveness of this strategy has been shown by several investigators in reducing the incidence of HBV carrier rate and probably cirrhosis and hepatocellular carcinoma (1, 2, 5-7). A level of 10 IU/L of anti hepatitis B surface antibody (Anti HBsAb) is usually considered as a protective level against future infections. Although this level was initially determined in studies about passive prophylaxis of HBV infection, the same level was arbitrary applied to active immunization though this was debated by some researchers (8-10). Universally there is a consistent dec 2011 Kowsar M.P.Co. All rights reserved. Please cite this paper as: Lankarani KB. The necessity of booster vaccination after neonatal hepatitis B vaccination. Hepat Mon. 2011;11(6):419-21.
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